Lissoni received a degree in architecture at the Polytechnic of Milan. After completing his studies he worked as a designer for Molteni and Lema.
In 1986 he founded 'Studio Lissoni' with Nicoletta Canesi, developing projects in architecture, interior architecture, design and graphic design. The studio also works in the field of art direction and public relations. He has worked with a wide range of design houses and manufacturers including Driade, Kartell, Artemide and Lema.